Methanol → 1-(2-Chloro-1,1-dimethyl-ethyl)-3-(4-methyl-pyridin-3-yl)-urea
반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH2:8].[Cl:9][CH2:10][C:11]([N:14]=[C:15]=[O:16])([CH3:13])[CH3:12].CO>C1(C)C=CC=CC=1.C(Cl)(Cl)Cl>[Cl:9][CH2:10][C:11]([NH:14][C:15]([NH:8][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:2]=1[CH3:1])=[O:16])([CH3:13])[CH3:12]참가 물질
6
실험 절차
4-Methyl-pyridin-3-ylamine (1.98 g, 18.33 mmol) was added to solution of 1-chloro-2-isocyanato-2-methyl-propane (I-200c: 3 g, 20.40 mmol) in toluene (30 mL). The resulting mixture was stirred at room temperature for 3 days. The reaction was monitored by TLC (5% MeOH in CHCl3). The reaction mixture was filtered and the residue was dried to afford 4.3 g of the product (87.75% yield).
후처리
- filtrationThe reaction mixture was filtered
- customthe residue was dried
출처 및 근거
- ORD 기록
- ord-b07c728c21cb48b78444794a121a8a1f
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- USRE045173E1
반응 노트
불러오는 중…