Hydrochloric Acid → Methyl (6Z)-7-hydroxy-7-(4-methylthiophenyl)-5-oxohept-6-enoate

온도

-72 °C

Lithium diisopropylamide mono(tetrahydrofuran) in cyclohexane (1.5 M; 28 mL, 42 mmol) was added to a solution of 1-(4-methylthiophenyl)ethan-1-one (5.16 g, 31 mmol) in THF (120 mL) and stirred for 30 minutes at −72° C. A solution of methyl 4-(chloroformyl)butyrate (1.78 g, 10.8 mmol) was added to the above solution and stirred for 30 minutes and then warmed slowly from the −72° C. to −45° C. To the reaction mixture was added 3N HCl (50 mL) and extracted with ethyl acetate (100 mL×3). The combined organic layers were washed with water, brine, dried over Na2SO4, filtered and evaporated. Trituration of the residue with diethyl ether/hexane gave a mixture of the title compound and starting material (˜30% yield) as a solid (2.42 g). The crude material was used in the next step without purification. A small quantity of pure sample was obtained at the beginning of the trituation. Mp. 92–93° C. 1H NMR (CDCl3) δ 15.1 (br, 1H), 7.79 (d, J=8.6 Hz, 2H), 7.27 (d, J=8.6 Hz, 2H), 6.13 (s, 1H), 3.69 (s, 3H), 2.52 (s, 3H), 2.48 (t, J=7.4 Hz, 2H), 2.42 (t, J=7.4 Hz, 2H), 2.02 (m, 2H). 13C NMR (CDCl3) δ 194.8, 183.0, 173.4, 144.9, 131.0, 127.3, 125.2, 95.6, 51.5, 37.9, 33.1, 20.8, 14.8.

1. stirringstirred for 30 minutes
2. temperaturewarmed slowly from the −72° C. to −45° C
3. extractionextracted with ethyl acetate (100 mL×3)
4. washThe combined organic layers were washed with water, brine
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customevaporated
8. customTrituration of the residue with diethyl ether/hexane gave

ORD 기록

ord-1855fff929db4ad5a02d92ae3b13462a

출처 데이터셋

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07087630B2