Phenol → [2,6-Dimethyl-4-(5-phenoxy-oxazolo[5,4-d]pyrimidin-2-yl)-phenoxy]-acetic acid tert-butyl ester

HRID 81384노트

반응식

HRID 81384 반응식
[H-].[Na+].[C:3]1([OH:9])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:10]([O:14][C:15](=[O:36])[CH2:16][O:17][C:18]1[C:23]([CH3:24])=[CH:22][C:21]([C:25]2[O:26][C:27]3[N:28]=[C:29](Cl)[N:30]=[CH:31][C:32]=3[N:33]=2)=[CH:20][C:19]=1[CH3:35])([CH3:13])([CH3:12])[CH3:11]>CC(N(C)C)=O>[C:10]([O:14][C:15](=[O:36])[CH2:16][O:17][C:18]1[C:23]([CH3:24])=[CH:22][C:21]([C:25]2[O:26][C:27]3[N:28]=[C:29]([O:9][C:3]4[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=4)[N:30]=[CH:31][C:32]=3[N:33]=2)=[CH:20][C:19]=1[CH3:35])([CH3:13])([CH3:12])[CH3:11]

참가 물질

5

반응물 3

HCID 996PhenolHCID 24758Sodium hydrideHCID 86679893[4-(5-Chloro-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid tert-butyl ester

생성물 1

HCID 86679894[2,6-Dimethyl-4-(5-phenoxy-oxazolo[5,4-d]pyrimidin-2-yl)-phenoxy]-acetic acid tert-butyl ester

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매2회

실험 절차

19 mg of sodium hydride were added under an argon atmosphere to a solution of 38 mg of phenol in 5 ml of dimethylacetamide. After stirring for 30 min at room temperature, a solution of 156 mg of [4-(5-chloro-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenoxy]-acetic acid tert-butyl ester in 3 ml of dimethylacetamide was added slowly. The mixture was allowed to stir for 1.5 h at room temperature. Upon consumption of the starting ester an aqueous solution of citric acid (100 g/l) was added until the pH was neutral. The aqueous layer was extracted twice with 15 ml ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered and the solvents were removed in vacuo. The title compound was isolated by silica gel chromatography (heptane/ethyl acetate gradient). Yield: 77 mg of a white solid.

후처리

  1. stirringto stir for 1.5 h at room temperature
  2. customUpon consumption of the starting ester an aqueous solution of citric acid (100 g/l)
  3. additionwas added until the pH
  4. extractionThe aqueous layer was extracted twice with 15 ml ethyl acetate
  5. dry with materialThe combined organic layers were dried over sodium sulfate
  6. filtrationfiltered
  7. customthe solvents were removed in vacuo

출처 및 근거

ORD 기록
ord-5894b2320fdc46bc8dee19f753a981e8
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846692B2

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