Formamide → 7-Fluoroquinazolin-4(3H)-one
반응식
[CH3:1][N-:2]C.[NH2:4][C:5]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:6]=1[C:7](O)=[O:8].C(N)=O>O>[F:14][C:12]1[CH:13]=[C:5]2[C:6]([C:7](=[O:8])[NH:2][CH:1]=[N:4]2)=[CH:10][CH:11]=1참가 물질
5
반응 조건
- 온도
- 180 °C
실험 절차
A catalytic amount (1 ml) of N,N-dimethylamide was added to 2-amino-4-fluorobenzoic acid (50 g, 322 mmol) and formamide (77 ml, 1934 mmol), and the resulting solution was stirred. The solution was heated to 180° C. and stirred for 14 hours. The temperature of the solution was cooled to room temperature, and 300 ml of distilled water was added thereto. The resulting solid was stirred about 30 min, and filtered to obtain the title compound 41.3 g (yield: 78%).
후처리
- stirringstirred for 14 hours
- temperatureThe temperature of the solution was cooled to room temperature
- stirringThe resulting solid was stirred about 30 min
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-c6d31f2832c24e03bae54d8181808b82
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846699B2
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