Formamide → 7-Fluoroquinazolin-4(3H)-one

HRID 81454

반응식

HRID 81454 반응식
[CH3:1][N-:2]C.[NH2:4][C:5]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:6]=1[C:7](O)=[O:8].C(N)=O>O>[F:14][C:12]1[CH:13]=[C:5]2[C:6]([C:7](=[O:8])[NH:2][CH:1]=[N:4]2)=[CH:10][CH:11]=1

참가 물질

5

반응물 3

HCID 713FormamideHCID 182180DimethylazanideHCID 27249674-Fluoroanthranilic acid

생성물 1

HCID 1353984967-Fluoroquinazolin-4(3H)-one수율 78%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
180 °C

실험 절차

A catalytic amount (1 ml) of N,N-dimethylamide was added to 2-amino-4-fluorobenzoic acid (50 g, 322 mmol) and formamide (77 ml, 1934 mmol), and the resulting solution was stirred. The solution was heated to 180° C. and stirred for 14 hours. The temperature of the solution was cooled to room temperature, and 300 ml of distilled water was added thereto. The resulting solid was stirred about 30 min, and filtered to obtain the title compound 41.3 g (yield: 78%).

후처리

  1. stirringstirred for 14 hours
  2. temperatureThe temperature of the solution was cooled to room temperature
  3. stirringThe resulting solid was stirred about 30 min
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-c6d31f2832c24e03bae54d8181808b82
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846699B2

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