m-Bromobenzenesulphonyl chloride → 1-(3-Bromobenzenesulfonyl)-4-methylpiperazine

HRID 81482

반응식

HRID 81482 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][C:9]1[CH:10]=[C:11]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1>N1C=CC=CC=1.Cl>[Br:8][C:9]1[CH:10]=[C:11]([S:15]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=1

참가 물질

5

반응물 2

HCID 17943m-Bromobenzenesulphonyl chlorideHCID 531671-Methylpiperazine

생성물 1

HCID 294021141-(3-Bromobenzenesulfonyl)-4-methylpiperazine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 1049Pyridine용매

실험 절차

A solution of 1-methylpiperazine (0.072 ml, 0.65 mmol) and 3-bromobenzene-1-sulfonyl chloride (0.2 g, 0.78 mmol) in pyridine (3 ml) is stirred at room temperature for 2 hours. The reaction mixture is diluted with 2M HCl, and extracted with DCM. The aqueous layer is made basic with 2M NaOH, and is extracted with DCM. The DCM layers are combined, dried (MgSO4) and the solvent removed in vacuo to afford the title compound as an orange oil. [M+H]+ 345.

후처리

  1. extractionextracted with DCM
  2. extractionis extracted with DCM
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-c748f04c3b984371bea84924a0a5c617
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846687B2

연결된 노트

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