Sodium Hydroxide → (2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone

HRID 81488노트

반응식

HRID 81488 반응식
CC(C)(C)C([NH:5][C:6]1[C:11]([C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:13])=[CH:10][CH:9]=[CH:8][N:7]=1)=O.[OH-].[Na+]>Cl>[NH2:5][C:6]1[C:11]([C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:13])=[CH:10][CH:9]=[CH:8][N:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 686311822,2-dimethyl-N-[3-(pyridine-3-carbonyl)-pyridin-2-yl]-propionamide

생성물 1

HCID 53678495(2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 2,2-dimethyl-N-[3-(pyridine-3-carbonyl)-pyridin-2-yl]-propionamide (0.225 g, 0.79 mmol) in 3M HCl (10 ml) is heated at reflux for 4 hours. The reaction mixture is allowed to cool to room temperature and the pH adjusted to basic with 2M NaOH. The product is extracted into DCM, dried (MgSO4), and concentrated in vacuo to afford a yellow solid. Drying in vacuo at 45° C. overnight yields (2-Amino-pyridin-3-yl)-pyridin-3-yl-methanone [M+H]+ 200.

후처리

  1. temperatureat reflux for 4 hours
  2. extractionThe product is extracted into DCM
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo
  5. customto afford a yellow solid
  6. customDrying in vacuo at 45° C. overnight

출처 및 근거

ORD 기록
ord-3147b6d8ef0a4ebe9c6078be1d95b6ee
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846687B2

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