Hydrochloric Acid → Sodium Chloride

HRID 81618노트

반응식

HRID 81618 반응식
C[O:2][C:3]([C:5]1[C:10]([NH2:11])=[N:9][C:8](OC)=[CH:7][N:6]=1)=[O:4].[OH-:14].[Na+:15].[ClH:16].[C:17]1(C)C=CC=CC=1>C1COCC1>[NH2:11][C:10]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][C:7]([O:14][CH3:17])=[CH:8][N:9]=1.[Cl-:16].[Na+:15]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 14798Sodium HydroxideHCID 53438909Methyl 3-amino-5-methoxypyrazine-2-carboxylate

생성물 2

HCID 5234Sodium ChlorideHCID 167380163-Amino-6-methoxypyrazine-2-carboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 200 mg (1.092 mmol) 3-amino-5-methoxy-pyrazine-2-carboxylic acid methyl ester in 4 ml THF was added 1.20 ml (1.20 mmol) i N sodium hydroxide and the mixture was stirred at room temperature for 29 h. To the mixture were added 1.09 ml (1.09 mmol) 1N HCl after stirring for 5 min toluene was added and the solvents were evaporated to provide the title compound together with sodium chloride as colorless solid. The mixture was used for coupling reactions without further purification.

후처리

  1. additionwas added
  2. customthe solvents were evaporated

출처 및 근거

ORD 기록
ord-ae70d9e4fbc240f39dbb9fefd5283c58
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846658B2

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