Pyridine → Ethanone, 2-(acetyloxy)-1-phenyl-
반응식
[OH:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].N1C=CC=CC=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>CN(C)C1C=CN=CC=1.ClCCl>[O:4]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:2][O:1][C:17](=[O:19])[CH3:18]참가 물질
6
실험 절차
A solution of 2-hydroxyaceto-phenone (10 g, 73.4 mmol), pyridine (17.4 g, 220.2 mmol), dichloromethane (734 mL), 3 crystals of 4-dimethylaminopyridine is cooled to −78° C. To this solution is added acetic anhydride (13.9 mL, 146.9 mmol) then warmed to room temperature and stirred for 18 h. The mixture is washed with water (200 mL) and brine (200 mL) then dried over sodium sulfate. The mixture is filtered and concentrated in vacuo to yield the title compound, 13 g (99%), as a colorless liquid.
후처리
- washThe mixture is washed with water (200 mL) and brine (200 mL)
- dry with materialthen dried over sodium sulfate
- filtrationThe mixture is filtered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-0a2ba70e58064169870e248f2da8307c
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087626B2
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