Pyridine → Ethanone, 2-(acetyloxy)-1-phenyl-

HRID 8191

반응식

HRID 8191 반응식
[OH:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].N1C=CC=CC=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>CN(C)C1C=CN=CC=1.ClCCl>[O:4]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:2][O:1][C:17](=[O:19])[CH3:18]

참가 물질

6

반응물 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 68490alpha-Hydroxyacetophenone

생성물 1

HCID 222851Ethanone, 2-(acetyloxy)-1-phenyl-

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

A solution of 2-hydroxyaceto-phenone (10 g, 73.4 mmol), pyridine (17.4 g, 220.2 mmol), dichloromethane (734 mL), 3 crystals of 4-dimethylaminopyridine is cooled to −78° C. To this solution is added acetic anhydride (13.9 mL, 146.9 mmol) then warmed to room temperature and stirred for 18 h. The mixture is washed with water (200 mL) and brine (200 mL) then dried over sodium sulfate. The mixture is filtered and concentrated in vacuo to yield the title compound, 13 g (99%), as a colorless liquid.

후처리

  1. washThe mixture is washed with water (200 mL) and brine (200 mL)
  2. dry with materialthen dried over sodium sulfate
  3. filtrationThe mixture is filtered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0a2ba70e58064169870e248f2da8307c
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087626B2

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