Hydrochloric Acid → 16864-90-7

HRID 82271

반응식

HRID 82271 반응식
C[O:2][C:3](=[O:14])[CH:4]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)[CH2:5][OH:6].O.[OH-].[Li+].Cl>C1COCC1.O>[Cl:13][C:10]1[CH:9]=[CH:8][C:7]([CH:4]([CH2:5][OH:6])[C:3]([OH:14])=[O:2])=[CH:12][CH:11]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 19914733Methyl 2-(4-chlorophenyl)-3-hydroxypropanoate

생성물 1

HCID 1260631016864-90-7수율 90%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 2-(4-Chloro-phenyl)-3-hydroxy-propionic acid methyl ester (Preparation 243, 500 mg, 2.33 mmol) in THF (7 mL) was added a solution of lithium hydroxide monohydrate (244 mg, 5.82 mmol) in water (2 mL) dropwise at 0° C. and the resulting mixture stirred at room temperature for 1 hour. The reaction mixture was acidified (pH˜3) with 2N hydrochloric acid and extracted with DCM (3×20 mL). The combined organic layers were washed with brine (10 mL), dried (Na2SO4) and evaporated in vacuo to afford the title compound as a white solid in 90% yield, 420 mg.

후처리

  1. extractionextracted with DCM (3×20 mL)
  2. washThe combined organic layers were washed with brine (10 mL)
  3. dry with materialdried (Na2SO4)
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-1ccbffc98ec94e3b829960ab464e10b3
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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