Ethanol → Ethyl 4-nitrophenylacetate

HRID 82287

반응식

HRID 82287 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].S(=O)(=O)(O)O.[OH-].[Na+].[CH2:21](O)[CH3:22]>>[CH2:21]([O:12][C:11](=[O:13])[CH2:10][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1)[CH3:22]

참가 물질

5

반응물 4

HCID 702EthanolHCID 1118Sulfuric AcidHCID 4661(4-Nitrophenyl)acetic acidHCID 14798Sodium Hydroxide

생성물 1

HCID 79517Ethyl 4-nitrophenylacetate수율 98%

실험 절차

To a stirred solution of (4-nitro-phenyl)-acetic acid (3 g, 16.4 mmol) in ethanol (30 mL) was added sulphuric acid (1 mL) and the reaction mixture was heated to reflux for 16 hours. The reaction mixture was neutralized with 2N aq. NaOH solution and extracted with EtOAc (3×50 mL). The combined organic layers were dried (Na2SO4) and evaporated in vacuo to afford the title compound as a light yellow oil in 98% yield, 3.4 g.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux for 16 hours
  3. extractionextracted with EtOAc (3×50 mL)
  4. dry with materialThe combined organic layers were dried (Na2SO4)
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-6b9f9ab498404a8ab71a0ea8bcffc870
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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