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Hydrochloric Acid → 3(1H-indol-3-yl)-2-[pyridine-3-carbonyl]-amino-propionic acid

HRID 82478
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인쇄 미리보기

반응식

HRID 82478 반응식
C[O:2][C:3](=[O:24])[C:4]([NH2:23])([C:15]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)=[O:16])[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1.C1COCC1.[Li+].[OH-].Cl>CO.O>[NH:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]([CH2:5][C:4]([NH2:23])([C:15]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)=[O:16])[C:3]([OH:24])=[O:2])=[CH:7]1
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참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 866749223(1H-indol-3-yl)-2-[pyridine-3-carbonyl]-amino-propionic acid methylester

생성물 1

HCID 673452343(1H-indol-3-yl)-2-[pyridine-3-carbonyl]-amino-propionic acid수율 99%

시약·촉매·용매 2

HCID 887
Methanol
용매
HCID 962Water용매

반응 조건

온도
25 °C

실험 절차

To a solution of 3(1H-indol-3-yl)-2-[pyridine-3-carbonyl]-amino-propionic acid methylester (0.5 g, 1.6 mmol), in methanol (5 mL), THF (9 mL) was added LiOH (0.39 g, 7.70 mmol), dissolved in water (3 mL), The mixture was allowed to stir at room temperature (25° C.) over 2 h. Stripped off solvent, acidified reaction mass with 1.5N HCl, extracted with ethylacetate (100 mL) dried over sodium sulphate and concentrated to obtain product as colorless solid (0.48 g, 99%).

후처리

  1. extractionextracted with ethylacetate (100 mL)
  2. dry with materialdried over sodium sulphate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8452d0274a8146efaf00e68d3255a582
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08846721B2

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