Methyl iodide → HCID 178503348, 화합물

HRID 82574

반응식

HRID 82574 반응식
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]1[SH:10].CI.[C:13]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:13][S:10][C:2]1[NH:3][C:4]2=[N:5][CH:6]=[CH:7][CH:8]=[C:9]2[N:1]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178527819HCID 178527819, 화합물

생성물 1

HCID 178503348HCID 178503348, 화합물수율 45.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 1H-imidazo[4,5-b]pyridine-2-thiol (2 g) in acetone (30 mL) were added MeI (0.910 ml) and K2CO3 (5.48 g) at room temperature. After stirring for 10 h, the mixture was concentrated under reduced pressure. The residue was purified by column chromatography (NH-silica gel, eluted with 10%-100% EtOAc in hexane) to give 2-(methylsulfanyl)-3H-imidazo[4,5-b]pyridine (1.0 g) as a white solid.

후처리

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customThe residue was purified by column chromatography (NH-silica gel, eluted with 10%-100% EtOAc in hexane)

출처 및 근거

ORD 기록
ord-552e96a795fb4545bccf28eb5db15d6d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846713B2

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