Methyl iodide → Methyl 2-fluoro-4-(trifluoromethyl)nicotinate

HRID 82664

반응식

[F:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:5]=[CH:4][N:3]=1.[C:15]([O-])([O-])=O.[K+].[K+].CI>>[F:1][C:2]1[C:7]([C:8]([O:10][CH3:15])=[O:9])=[C:6]([C:11]([F:12])([F:13])[F:14])[CH:5]=[CH:4][N:3]=1

참가 물질

반응물 3

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 283077662-Fluoro-4-(trifluoromethyl)pyridine-3-carboxylic acid

생성물 1

HCID 58577652Methyl 2-fluoro-4-(trifluoromethyl)nicotinate수율 99.9%

실험 절차

To a mixture of 2-fluoro-4-(trifluoromethyl)pyridine-3-carboxylic acid (1.06 g) and K2CO3 (0.701 g) in DMF(dry) (10 mL) was added MeI (0.317 ml). The mixture was stirred at room temperature for 3 h. The mixture was directly purified by column chromatography (silica gel, EtOAc/hexane) to give the title compound (1.13 g, containing EtOAc and hexane, ca. 75% purity).

후처리

customThe mixture was directly purified by column chromatography (silica gel, EtOAc/hexane)

출처 및 근거

ORD 기록: ord-6302aff528d24ad7b6dc61b4c1fada97
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08846713B2

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