2-[4-(3-Chloro-propoxy)-phenyl]-imidazo[1,2-a]pyridine → 2-[4-(3-Chloro-propoxy)-phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine

HRID 8361

반응식

HRID 8361 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]3[CH:20]=2)=[CH:8][CH:7]=1>C(O)C.CO.[Pt](=O)=O>[Cl:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[CH2:19][CH2:18][CH2:17][CH2:16][N:15]3[CH:20]=2)=[CH:8][CH:7]=1

참가 물질

5

반응물 1

HCID 140970942-[4-(3-Chloro-propoxy)-phenyl]-imidazo[1,2-a]pyridine

생성물 1

HCID 220156272-[4-(3-Chloro-propoxy)-phenyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine수율 96.4%

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매HCID 887Methanol용매

실험 절차

To a Parr bottle charged with a mixture of platinum (IV) oxide (30 mg) in ethanol (3 mL) was added a solution of the product of Step A (90 mg) in methanol (6 ml). The mixture was hydrogenated at 40 psi for 4 hours and filtered through a Celite pad which was rinsed with several additional milliliters of methanol and ethanol. The filtrate was collected and evaporated in vacuo to yield the title compound (88 mg) which was used without further purification.

후처리

  1. filtrationfiltered through a Celite pad which
  2. washwas rinsed with several additional milliliters of methanol and ethanol
  3. customThe filtrate was collected
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-838c0cefe9b94edaae563cc0b0c31601
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087757B2

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