Hydrochloric Acid → 1-[(4-Chlorophenyl)methyl]-1H-imidazole-2-carboxylic acid

HRID 83659노트

반응식

HRID 83659 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][N:9]=[C:8]2[C:12]([O:14]CC)=[O:13])=[CH:4][CH:3]=1.[OH-].[Na+].O.Cl>CCO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][N:9]=[C:8]2[C:12]([OH:14])=[O:13])=[CH:17][CH:18]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68379775ethyl 1-(4-chlorobenzyl)-1H-imidazole-2-carboxylate

생성물 1

HCID 683797411-[(4-Chlorophenyl)methyl]-1H-imidazole-2-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 1-(4-chlorobenzyl)-1H-imidazole-2-carboxylate (7.28 g, 27.5 mmol), was dissolved in EtOH (10 mL) and 10% aq. NaOH (20 mL) and stirred at rt for 15 h. The solvent was then stripped off, water was added, and the solution acidified with HCl. The resulting precipitate was collected over a filter and washed with 1M HCl and dried to afford the title compound as a white powder without further characterization. (Yield: 6.506 g, 27.5 mmol, 100%)

후처리

  1. customThe resulting precipitate was collected over
  2. filtrationa filter
  3. washwashed with 1M HCl
  4. customdried

출처 및 근거

ORD 기록
ord-a420a9d85db14e7db51511543c07ec47
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846684B2

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