Hydrochloric Acid → 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylic acid

HRID 83683노트

반응식

HRID 83683 반응식
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([CH3:16])=[C:8]2[C:17]([O:19]CC)=[O:18])=[CH:4][CH:3]=1.[OH-].[Na+].O.Cl>CCO>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]([CH3:16])=[C:8]2[C:17]([OH:19])=[O:18])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68380183ethyl 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylate

생성물 1

HCID 683797421-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

ethyl 1-(4-chlorobenzyl)-3-methyl-1H-indole-2-carboxylate (480 mg, 1.46 mmol) was dissolved in EtOH (15 mL) and 10% aq. NaOH was added (6 mL). The reaction was allowed to stir at rt for 32 h, at which time as much solvent was stripped off as possible, water was added, and the mixture cooled in an ice bath. The mixture was acidified with concentrated HCl and the precipitate collected over a filter. The title compound was obtained as a white powder that was not purified or characterized further. (Yield: 430 mg, 1.435 mmol, 98%)

후처리

  1. additionwas added
  2. temperaturethe mixture cooled in an ice bath
  3. customthe precipitate collected over a filter

출처 및 근거

ORD 기록
ord-3b5ed9349d8747cb9ec225d9d34ca73a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846684B2

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