2-Amino-4-methylpyridine → 2-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide

HRID 8371

반응식

HRID 8371 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][Cl:15])=[C:7]([O:16][CH3:17])[CH:6]=1)=O.[NH2:18][C:19]1[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][N:20]=1>C(O)C>[BrH:1].[Cl:15][CH2:14][CH2:13][CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:18]=[C:19]3[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][N:20]3[CH:2]=2)=[CH:6][C:7]=1[O:16][CH3:17]

참가 물질

4

반응물 2

HCID 15332-Amino-4-methylpyridineHCID 22015629alpha-Bromo-3'-methoxy-4'-chloropropoxyacetophenone

생성물 1

HCID 220155982-(4'-Chloropropoxy-3'-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide수율 70.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of the product of Step B (1.44 g) and 2-amino-4-picoline (0.486 g) in ethanol (6 mL) was heated at 73° C. for 1 hour. The reaction mixture was cooled to ambient temperature and evaporated to a yellow solid. The solid was stirred with 25 mL of dichloromethane for approximately 10 minutes. The mixture was filtered and the solid product collected to yield the title compound (1.3 g).

후처리

  1. customevaporated to a yellow solid
  2. filtrationThe mixture was filtered
  3. customthe solid product collected

출처 및 근거

ORD 기록
ord-979a976b36f74db790007f7dd4f936ca
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087757B2

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