2-Amino-4-methylpyridine → 2-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine

HRID 8376

반응식

HRID 8376 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1>C(O)C>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:12]=[C:13]3[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]3[CH:2]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 15332-Amino-4-methylpyridineHCID 74544-Bromophenacyl bromide

생성물 1

HCID 7176442-(4-Bromophenyl)-7-methylimidazo[1,2-a]pyridine수율 56.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2,4′-dibromoacetophenone (22.4 g) and 2-amino-4-picoline (8.68 g) in ethanol (80 mL) was heated at reflux temperature for 3 hours. The reaction mixture was cooled to ambient temperature and the crystalline solid isolated by filtration, washed with ethanol and dried in vacuo to give the title compound (13.1 g).

후처리

  1. temperaturewas heated
  2. temperatureat reflux temperature for 3 hours
  3. customthe crystalline solid isolated by filtration
  4. washwashed with ethanol
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-e6db157d18cf461c8d370ac086ebe049
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087757B2

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