Ethanol → 2-[4-Hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine

반응식

[CH:1]1[C:6]([C:7]([CH2:9]Br)=O)=[CH:5][CH:4]=[C:3]([OH:11])[CH:2]=1.[NH2:12][C:13]1(C)[CH:18]=[CH:17][CH:16]=[CH:15][NH:14]1.[CH2:20](O)C>>[OH:11][C:3]1[CH:4]=[CH:5][C:6]([C:7]2[N:12]=[C:13]3[C:18]([CH3:20])=[CH:17][CH:16]=[CH:15][N:14]3[CH:9]=2)=[CH:1][CH:2]=1

참가 물질

반응물 3

HCID 702Ethanol

HCID 49642-Bromo-1-(4-hydroxyphenyl)ethanone

HCID 668245222-Aminopicoline

생성물 1

HCID 220156592-[4-Hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine

실험 절차

The product of step A (30 g) and 2-aminopicoline (15 mL) in ethanol (200 mL) was heated at reflux temperature for 4 hours then cooled to ambient temperature. The resulting precipitate containing the title compound was isolated via filtration (27 g).