Ethanol → 2-[4-Hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine

HRID 8384

반응식

HRID 8384 반응식
[CH:1]1[C:6]([C:7]([CH2:9]Br)=O)=[CH:5][CH:4]=[C:3]([OH:11])[CH:2]=1.[NH2:12][C:13]1(C)[CH:18]=[CH:17][CH:16]=[CH:15][NH:14]1.[CH2:20](O)C>>[OH:11][C:3]1[CH:4]=[CH:5][C:6]([C:7]2[N:12]=[C:13]3[C:18]([CH3:20])=[CH:17][CH:16]=[CH:15][N:14]3[CH:9]=2)=[CH:1][CH:2]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 49642-Bromo-1-(4-hydroxyphenyl)ethanoneHCID 66824522HCID 66824522, 화합물

생성물 1

HCID 220156592-[4-Hydroxyphenyl]-8-methylimidazo[1,2-a]pyridine

실험 절차

The product of step A (30 g) and 2-aminopicoline (15 mL) in ethanol (200 mL) was heated at reflux temperature for 4 hours then cooled to ambient temperature. The resulting precipitate containing the title compound was isolated via filtration (27 g).

후처리

  1. temperatureat reflux temperature for 4 hours

출처 및 근거

ORD 기록
ord-b69a26f17c554d17b35eebf5deba32e4
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087757B2

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