Hydrochloric Acid → HCID 20318415, 화합물

HRID 838837노트

반응식

HRID 838837 반응식
[C:1]([C:5]1[C:6]([OH:19])=[C:7]([CH3:18])[C:8]([CH3:17])=[C:9]([CH2:11][CH2:12][C:13]([O:15]C)=[O:14])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].Cl>C(O)C.O>[C:1]([C:5]1[C:6]([OH:19])=[C:7]([CH3:18])[C:8]([CH3:17])=[C:9]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20318402HCID 20318402, 화합물

생성물 1

HCID 20318415HCID 20318415, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

Under nitrogen, a solution of methyl 3-(5-tert.-butyl-2,3-dimethyl-4 -hydroxyphenyl)propionate (71.5 g) in 150 ml of ethanol was treated with a solution of 98% sodium hydroxide (12.1 g) in 15 ml of water, and the mixture was heated under reflux for 3 hours. The cold solution was diluted with water to about 1200 ml and then acidified with concentrated hydrochloric acid. The precipitated solid was filtered off and washed with water. Recrystallization from 600 ml of acetonitrile gave the acid, m.p. 191° to 193° C.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. filtrationThe precipitated solid was filtered off
  4. washwashed with water
  5. customRecrystallization from 600 ml of acetonitrile
  6. customgave the acid, m.p. 191° to 193° C.

출처 및 근거

ORD 기록
ord-9e69561d7ec940698bb3fe626cb0a7a0
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04093587

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