Chloromethyl Methyl Ether → Methyl alpha-amino-alpha-(4-methoxymethoxyphenyl)acetate

HRID 839449

반응식

HRID 839449 반응식
[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[C:3]([O:5][CH3:6])=[O:4].[H-].[Na+].[H][H].[CH3:18][O:19][CH2:20]Cl>O.CN(C)C=O>[NH2:1][CH:2]([C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:18][O:19][CH3:20])=[CH:11][CH:12]=1)[C:3]([O:5][CH3:6])=[O:4]

참가 물질

7

반응물 4

HCID 7864Chloromethyl Methyl EtherHCID 24758Sodium hydrideHCID 4123006p-Hydroxyphenylglycine methyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 20324417Methyl alpha-amino-alpha-(4-methoxymethoxyphenyl)acetate

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

In this preparation 1.81 g. of methyl α-amino-α-(4-hydroxyphenyl)acetate is dissolved in 10 ml. of dimethylformamide under nitrogen and 0.24 g. of sodium hydride is then added. The solution is stirred at room temperature under nitrogen until hydrogen evolution ceases and then 0.80 g. of chloromethyl methyl ether is added. The resulting mixture is warmed at 60° C for 1 hour and then cooled and diluted with water. The aqueous mixture is extracted with ether and the ether extract is dried and evaporated to afford methyl α-amino-α-(4-methoxymethoxyphenyl)acetate.

후처리

  1. customIn this preparation 1.81 g
  2. temperaturecooled
  3. extractionThe aqueous mixture is extracted with ether
  4. extractionthe ether extract
  5. customis dried
  6. customevaporated

출처 및 근거

ORD 기록
ord-b59e5b18ad26420caf07f211fcad7334
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04094978

연결된 노트

불러오는 중…