Ammonium Acetate → 5,6-Dichloro-indan-1-ylamine

HRID 839519노트

반응식

HRID 839519 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[Cl:11])[C:7](=O)[CH2:6][CH2:5]2.C([O-])(=O)C.[NH4+].C([BH3-])#[N:19].[Na+]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[Cl:11])[CH:7]([NH2:19])[CH2:6][CH2:5]2

참가 물질

4

반응물 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 229036095,6-Dichloro-2,3-dihydro-1H-inden-1-one

생성물 1

HCID 203234005,6-Dichloro-indan-1-ylamine

실험 절차

Following the procedure of Example 1, 5,6-dichloro-1-indanone was reacted with ammonium acetate and sodium cyanoborohydride to yield 5,6-dichloro-1-aminoindane; yield = 670 mg. The crystalline compound was treated with 360 mg. of maleic acid in 25 ml. of isopropanol. The maleate salt crystallized and was separated by filtration. Recrystallization of the salt from a 1:3 isopropanol/ethyl acetate solvent mixture yielded 650 mg. of 5,6-dichloro-1-aminoindane maleate melting at 167°-170° C.

출처 및 근거

ORD 기록
ord-ff672ca82f8f47aca19d173fbfa32228
출처 데이터셋
uspto-grants-1978_06
특허 번호
US04096173

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