1,2-Dichlorobenzene → 3,4-Dichlorobenzophenone

HRID 840497

반응식

HRID 840497 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[Cl:21]>C1(C)C=CC=CC=1>[Cl:14][C:15]1[CH:20]=[C:19]([CH:18]=[CH:17][C:16]=1[Cl:21])[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:8]

참가 물질

5

반응물 3

HCID 72391,2-DichlorobenzeneHCID 7412Benzoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 804943,4-Dichlorobenzophenone수율 346.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

70.3 g of benzoyl chloride was added into the mixture of aluminium chloride (93.3 g) and 1,2-dichloro benzene (14.7 g) using 500 mL three necked flask, then reaction was carried out for 12 hrs. at 120° C. The reaction mixture was poured into 1000 g of ice water in a beaker (5000 mL), and further, 1000 g of toluene was added. The toluene layer was washed by 1000 g of water three times. After condensing the toluene layer under reduced pressure, 87 g of 3,4-dichlorobenzophenone was obtained (yield 69%)

후처리

  1. customreaction
  2. customat 120° C
  3. washThe toluene layer was washed by 1000 g of water three times
  4. customAfter condensing the toluene layer under reduced pressure

출처 및 근거

ORD 기록
ord-2e30c203c3064bd4a1263a3cb23a84a1
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06368769B1

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