Desipramine Hydrochloride → Desipramine

HRID 840510

반응식

HRID 840510 반응식
[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][N:6]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[CH2:14][CH2:13][C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]1=2.Cl>[OH-].[Na+]>[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][N:6]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]1=2

참가 물질

3

반응물 1

HCID 65327Desipramine Hydrochloride

생성물 1

HCID 2995Desipramine수율 99.1%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

To 6.02 g of desipramine hydrochloride was added 150 ml of 1N NaOH. The mixture was allowed to stir for 10 minutes. The aqueous mixture was extracted with 6×100 ml of chloroform. The combined chloroform layer was washed with 200 ml of water. The organic part was dried (Na2SO4) and concentrated to give 5.25 g of desipramine free base.

후처리

  1. extractionThe aqueous mixture was extracted with 6×100 ml of chloroform
  2. washThe combined chloroform layer was washed with 200 ml of water
  3. dry with materialThe organic part was dried (Na2SO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-78cbff80e04c44a7a384b30c58aff007
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06368814B1

연결된 노트

불러오는 중…