반응식
[NH2:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]([C:13]2[C:14]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)=[CH:15][CH:16]=[CH:17][CH:18]=2)=[O:12])[CH:5]=[CH:6][C:7]=1C=O.[C:29]([O:35][CH2:36][CH3:37])(=[O:34])[CH2:30][C:31]([CH3:33])=O.[OH-].[Na+].[C:40](O)(=O)C>O>[CH2:36]([O:35][C:29]([C:30]1[C:31]([CH3:33])=[N:1][C:2]2[C:7]([CH:40]=1)=[CH:6][CH:5]=[C:4]([NH:10][C:11]([C:13]1[C:14]([C:19]3[CH:20]=[CH:21][C:22]([C:25]([F:26])([F:28])[F:27])=[CH:23][CH:24]=3)=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:12])[CH:3]=2)=[O:34])[CH3:37]참가 물질
6
반응물 4
생성물 1
시약·촉매·용매 1
실험 절차
4′-Trifluoromethyl-biphenyl-2-carboxylic acid (3-amino-4-formyl-phenyl)-amide (769 mg, 2.0 mmol) and ethyl acetoacetate (260 mg, 2.0 mmol) were dissolved in 10 ml of acetic acid and heated at 80 C. After 2.5 h, the mixture was cooled to room temperature, diluted with water and brought to pH 10 with 2N NaOH. The mixture was extracted with ethyl acetate (2×50 ml), the combined organic layers washed with brine, dried over magnesium sulfate, and concentrated to give 815 mg of a yellow solid. This material was purified by chromatography on silica gel eluting with 0 to 10% ethyl acetate in dichloromethane to provide 349 mg (36%) of the title compound as a yellow foam.
후처리
- temperatureheated at 80 C
- extractionThe mixture was extracted with ethyl acetate (2×50 ml)
- washthe combined organic layers washed with brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-732dea66da874e72a06cb8339b87576d
- 출처 데이터셋
- uspto-grants-2002_04
- 특허 번호
- US06369075B1
연결된 노트
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