Chloromethyl Methyl Ether → 3-Chloro-4-methoxymethoxy-5-methyl-1-benzoyloxybenzene

HRID 842576노트

반응식

HRID 842576 반응식
[C:1]([O:9][C:10]1[CH:15]=[C:14]([CH3:16])[C:13]([OH:17])=[C:12]([Cl:18])[CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:19][O:20][CH2:21]Cl.C(N(C(C)C)C(C)C)C>C(Cl)(Cl)Cl>[Cl:18][C:12]1[CH:11]=[C:10]([O:9][C:1](=[O:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:15]=[C:14]([CH3:16])[C:13]=1[O:17][CH2:19][O:20][CH3:21]

참가 물질

5

반응물 3

HCID 7864Chloromethyl Methyl EtherHCID 81531DiisopropylethylamineHCID 185045884-Benzoyloxy-2-chloro-6-methylphenol

생성물 1

HCID 185046333-Chloro-4-methoxymethoxy-5-methyl-1-benzoyloxybenzene수율 96%

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
0 °C

실험 절차

Then, 25 g of 4-benzoyloxy-2-chloro-6-methylphenol was dissolved in 250 ml of chloroform, to which 12 g of chloromethyl methyl ether was added, while stirring at 0° C., and 21 g of N-ethyldiisopropylamine was added dropwise. After heating under reflux for 1 hour, the chloroform layer was washed with water, and concentrated. The residue was subjected to silica gel chromatography, which afforded 27.4 g of 3-chloro-4-methoxymethoxy-5-methyl-1-benzoyloxybenzene (96% yield).

후처리

  1. additionwas added
  2. temperatureAfter heating
  3. temperatureunder reflux for 1 hour
  4. washthe chloroform layer was washed with water
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d3f0aacf39eb4c08a6d620dbaa3ea39b
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376428B1

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