Triethylamine → 3-amino-1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile

HRID 842707

반응식

HRID 842707 반응식
O.[NH2:2][NH2:3].Cl[C:5]1[C:10]([C:11]#[N:12])=[CH:9][C:8]([C:13]#[N:14])=[CH:7][N:6]=1.C(N(CC)CC)C>C(O)C>[C:13]([C:8]1[CH:9]=[C:10]2[C:5](=[N:6][CH:7]=1)[NH:3][N:2]=[C:11]2[NH2:12])#[N:14]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 24654Hydrazine hydrate (1:1)HCID 109865792-Chloropyridine-3,5-dicarbonitrile

생성물 1

HCID 1785103343-amino-1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

Hydrazine hydrate (55%, 125 μL, 2.20 mmol) was added to a stirred suspension of 2-chloro-3,5-dicyanopyridine (240 mg, 1.47 mmol) and triethylamine (205 μL, 1.47 mmol) in ethanol (3 mL) and the resulting red mixture was heated to 60° C. After 16 h the mixture was cooled and filtered to give the title compound:

후처리

  1. temperatureAfter 16 h the mixture was cooled
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-7bac2a1c9f9e468fa8fa8cecea7a7103
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376499B1

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