Pyruvic Acid → 2-(2,3,4-Trifluoroanilino)propionic acid

HRID 8438

반응식

HRID 8438 반응식
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[N+:10]([O-])=O.[C:13]([OH:18])(=[O:17])[C:14]([CH3:16])=O.[H][H]>C(O)(C)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:14]([CH3:16])[C:13]([OH:18])=[O:17]

참가 물질

6

반응물 3

HCID 1060Pyruvic AcidHCID 698711,2,3-Trifluoro-4-nitrobenzeneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 220158662-(2,3,4-Trifluoroanilino)propionic acid수율 98.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 3776Isopropanol용매

실험 절차

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in isopropanol (IPA; 40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under atmospheric pressure in a hydrogen atmosphere for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.11 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

후처리

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d2ae1fef10194c6597c1745779551014
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087778B2

연결된 노트

불러오는 중…