Pyruvic Acid → 2-(2,3,4-Trifluoroanilino)propionic acid
반응식
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[N+:10]([O-])=O.[C:13]([OH:18])(=[O:17])[C:14]([CH3:16])=O>CC(O)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:14]([CH3:16])[C:13]([OH:18])=[O:17]참가 물질
5
반응 조건
- 온도
- 40 °C
실험 절차
2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.09 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.
후처리
- filtrationAfter filtering off Pd—C
- concentrationthe obtained filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-000aaf21ce6b430c92135e59c6c72ea3
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087778B2
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