Pyruvic Acid → 2-(2,3,4-Trifluoroanilino)propionic acid

HRID 8439

반응식

HRID 8439 반응식
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[N+:10]([O-])=O.[C:13]([OH:18])(=[O:17])[C:14]([CH3:16])=O>CC(O)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:14]([CH3:16])[C:13]([OH:18])=[O:17]

참가 물질

5

반응물 2

HCID 1060Pyruvic AcidHCID 698711,2,3-Trifluoro-4-nitrobenzene

생성물 1

HCID 220158662-(2,3,4-Trifluoroanilino)propionic acid수율 97.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 3776Isopropanol용매

반응 조건

온도
40 °C

실험 절차

2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.09 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.

후처리

  1. filtrationAfter filtering off Pd—C
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-000aaf21ce6b430c92135e59c6c72ea3
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087778B2

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