C(N)CC1C=CC=CC=1.FC(F)(F)C(Cl)=O.[F:17][C:18]([F:30])([F:29])[CH:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][NH:20]1.C1C2C(=CC=CC=2)C=CN=1.[OH-].[Na+].[Cl:43][CH:44]([Cl:48])[C:45](Cl)=[O:46]>O.C(Cl)Cl>[Cl:43][CH:44]([Cl:48])[C:45]([N:20]1[CH2:21][CH2:22][C:23]2[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:19]1[C:18]([F:17])([F:29])[F:30])=[O:46]By procedures described in Example 1 (Method A), phenethylamine and trifluoroacetyl chloride were converted to 1-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline. A reaction vessel was charged with 3.5 g of this isoquinoline compound, 20 ml 10% sodium hydroxide and 50 ml methylene chloride. With this mixture stirred, 2 ml dichloroacetyl chloride was added dropwise to the mixture. The mixture was stirred for 2 minutes, then water was added. The organic extract was dried with magnesium sulfate, stripped of solvent, and subjected to Kugelrohr distillation (130° C. @ 0.1 mm Hg) to provide a product having the elemental analysis reported in Table I.
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