Hydrochloric Acid → 4-Acetoxymethylindole

HRID 845230

반응식

HRID 845230 반응식
[OH:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.[C:12](OC(=O)C)(=[O:14])[CH3:13].Cl.C(=O)(O)[O-].[Na+]>N1C=CC=CC=1.O.CCOCC>[C:12]([O:1][CH2:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2)(=[O:14])[CH3:13]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 27734571H-indol-4-ylmethanol

생성물 1

HCID 201323834-Acetoxymethylindole

시약·촉매·용매 3

HCID 962Water용매HCID 1049Pyridine용매HCID 3283Diethyl Ether용매

실험 절차

4-Hydroxymethylindole (17 g) is heated in pyridine (12 ml) with acetic anhydride (11.9 ml) for three hours on the steam bath. After dilution with ether, the reaction mixture is first shaken out with 1N hydrochloric acid, then with saturated sodium bicarbonate solution and finally with water. The ether solution is evaporated. 20 g of 4-acetoxymethylindole remains.

후처리

  1. customThe ether solution is evaporated

출처 및 근거

ORD 기록
ord-83b329542d554a09a2c16b88a5e07644
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04757070

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