Hydrochloric Acid → 1H-Indazole-3-carboxylic acid, 1-methyl-

HRID 846597

반응식

HRID 846597 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([O:13]C)=[O:12])=[N:3]1.[OH-].[Na+].Cl>CO.O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([OH:13])=[O:12])=[N:3]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13900574Methyl 1-methyl-1H-indazole-3-carboxylate

생성물 1

HCID 6891051H-Indazole-3-carboxylic acid, 1-methyl-수율 92%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 1-methylindazole-3-carboxylic acid, methyl ester (1.00 g, 0.0053 mole; was stirred in a mixture of methanol (10 ml)/2N NaOH solution (120 ml) at reflux temperature for 2 hours. After cooling, the mixture was diluted with water (100 ml) and acidified with 6N HCl solution. The white solid that formed was collected by filtration and dried under ambient conditions for 6 days to give 0.86 g (92% yield) of the product; mp 215°-216° C.

후처리

  1. temperatureat reflux temperature for 2 hours
  2. temperatureAfter cooling
  3. customThe white solid that formed
  4. filtrationwas collected by filtration
  5. customdried under ambient conditions for 6 days

출처 및 근거

ORD 기록
ord-43754bed1c39445a92a6663e5e0e6ce6
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05137895

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