Isobutyramide → [1-Dimethylamino-meth-(e)-ylidene]-isobutyramide

반응식

[C:1]([NH2:6])(=[O:5])[CH:2]([CH3:4])[CH3:3].[CH3:7][N:8]([CH:10](OC)OC)[CH3:9]>>[CH3:7][N:8]([CH3:10])/[CH:9]=[CH:3]/[CH:2]([CH3:4])[C:1]([NH2:6])=[O:5]

참가 물질

반응물 2

HCID 68424Isobutyramide

HCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 87184356[1-Dimethylamino-meth-(e)-ylidene]-isobutyramide

실험 절차

Following the procedure for 449, Step 3, isobutyramide was reacted with DMF-DMA to afford the title compound as a yellow oil. 1H NMR (CDCl3): 8.39 (1 H, s), 3.10 (3 H, m), 3.07 (3 H, d, J=0.67 Hz), 2.68-2.56 (1 H, m), 1.17 (3 H, s), 1.18-1.11 (3 H, s).

출처 및 근거

ORD 기록: ord-07cbee89ad884b72a7c66f70640ceb4a
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08846762B2

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