Hydrochloric Acid → HCID 21950839, 화합물

HRID 848833

반응식

HRID 848833 반응식
Cl[C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[SH:16][CH2:17][CH2:18][OH:19].C([O-])([O-])=O.[K+].[K+].Cl>CCOCC.O.CC(CC)=O>[OH:19][CH2:18][CH2:17][S:16][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 15672-MercaptoethanolHCID 86534-ChlorobenzophenoneHCID 11430Potassium Carbonate

생성물 1

HCID 21950839HCID 21950839, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 3283Diethyl Ether용매HCID 6569Methyl Ethyl Ketone용매

실험 절차

11.2 g (0.05 mol) of 4-chlorobenzophenone, 4.3 g (0.055 mol) of 2-mercaptoethanol, 13.8 g (0.1 mol) of calcined K2CO3 and 15 ml of ethyl methyl ketone are warmed (under reflux) for 16 hours under nitrogen. 50 ml of water are poured over the cooled reaction mixture and the resulting mixture is acidified with HCl. The product is taken up in ether. The ether layer is washed with water, dried over Na2SO4 and concentrated. The product, which in this case also is obtained as an oil, crystallises on standing. It is boiled up in hexane as described in (a). Yield: 10.0 g (77%). Melting point 49°-51°.

후처리

  1. temperature(under reflux) for 16 hours under nitrogen
  2. washThe ether layer is washed with water
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customThe product, which in this case also is obtained as an oil
  6. customcrystallises

출처 및 근거

ORD 기록
ord-9941b0fc29e94f388b43e9e54f2d37fe
출처 데이터셋
uspto-grants-1981_10
특허 번호
US04297513

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