Hydrochloric Acid → 2-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid

HRID 85144노트

반응식

HRID 85144 반응식
C([O:3][C:4]([C:6]1[C:7]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:21]([F:24])([F:23])[F:22])[NH:12][C:8]=2[CH:9]=[N:10][CH:11]=1)=[O:5])C.Cl>[OH-].[Na+].C(O)C>[F:24][C:21]([F:22])([F:23])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:13]1[NH:12][C:8]2[CH:9]=[N:10][CH:11]=[C:6]([C:4]([OH:5])=[O:3])[C:7]=2[N:14]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 672030302-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester

생성물 1

HCID 672044002-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid수율 85%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

2-(2-Trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid ethyl ester (80; 2.35 g, 7 mmol) was taken up in 10% aqueous NaOH (40 mL) and ethanol (20 mL). The reaction mixture was stirred under reflux for 30 min. Upon cooling to room temperature, the reaction mixture was acidified with 5N HCl. The resulting yellow solids were collected by filtration, washed with water, and dried to afford 2-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-c]pyridine-7-carboxylic acid 81 (1.77 g, 85%).

후처리

  1. temperatureunder reflux for 30 min
  2. filtrationThe resulting yellow solids were collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-2ecdf8d9e0bd4a57b471a76896c109d5
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846947B2

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