Sulfuric Acid → Dimedone

HRID 851802

반응식

HRID 851802 반응식
[O:1]=[C:2]([CH3:11])[CH2:3][C:4]([CH3:10])([CH3:9])[CH2:5][C:6](O)=[O:7].S(=O)(=O)(O)O>C(Cl)(Cl)Cl>[CH3:9][C:4]1([CH3:10])[CH2:3][C:2](=[O:1])[CH2:11][C:6](=[O:7])[CH2:5]1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 113326103,3-Dimethyl-5-oxohexanoic acid

생성물 1

HCID 31358Dimedone수율 82.3%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of 5 parts of 5-keto-3,3-dimethylhexanoic acid and about 15 parts of 73% sulfuric acid was heated for one hour in a 130°-135° oil bath. The cooled solution was then poured into a separatory funnel containing ice and chloroform. The aqueous phase was then washed three times with additional chloroform. The combined organic extractions were then dried and evaporated. There was obtained an 82.3% yield of dimedone. It was further recrystallized from toluene.

후처리

  1. additionThe cooled solution was then poured into a separatory funnel
  2. washThe aqueous phase was then washed three times with additional chloroform
  3. extractionThe combined organic extractions
  4. customwere then dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-d7eca5d1c32145dd995fe32b68df792d
출처 데이터셋
uspto-grants-1983_05
특허 번호
US04386222

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