Hydrochloric Acid → HCID 69198141, 화합물

HRID 851904노트

반응식

HRID 851904 반응식
[O:1]=[S:2]1(=[O:26])[C:7]2[CH:8]=[C:9]([O:12][C:13]3[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=3)[C:16]([O:18]C)=[O:17])[CH:10]=[CH:11][C:6]=2[N:5]2[CH2:23][CH2:24][CH2:25][C:4]2=[N:3]1.Cl.[OH-:28].[Na+]>>[NH2:3][S:2]([C:7]1[CH:8]=[C:9]([CH:10]=[CH:11][C:6]=1[N:5]1[CH2:23][CH2:24][CH2:25][C:4]1=[O:28])[O:12][C:13]1[CH:14]=[C:15]([CH:20]=[CH:21][CH:22]=1)[C:16]([OH:18])=[O:17])(=[O:26])=[O:1]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69414424HCID 69414424, 화합물

생성물 1

HCID 69198141HCID 69198141, 화합물

반응 조건

온도
95 °C

실험 절차

A suspension of the product obtained in Step A (1.1 g, 2.55 mmol) in 18 ml of 1N NaOH is heated at 95° C. until a solution is obtained. The solution is allowed to return to ambient temperature, is acidified with 1N HCl and extracted (CH2Cl2). The organic phases are combined, washed (saturated NaCl), dried (MgSO4) and evaporated. The residue is triturated in Et2O; the title product precipitates out and is recovered by filtration.

후처리

  1. customis obtained
  2. customto return to ambient temperature
  3. extractionextracted (CH2Cl2)
  4. washwashed (saturated NaCl)
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customThe residue is triturated in Et2O
  8. customthe title product precipitates out
  9. filtrationis recovered by filtration

출처 및 근거

ORD 기록
ord-adc6694200354603bd574a2eea76fbad
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07253162B2

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