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Triethylamine → 3-(2-Methyl-4-{[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-carbamoyl}-phenyl)-propionic acid ethyl ester

HRID 854564
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HRID 854564 반응식
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:17][NH2:18].[C:19]([CH2:22][CH2:23][C:24]1[CH:32]=[CH:31][C:27]([C:28]([OH:30])=O)=[CH:26][C:25]=1[CH3:33])([OH:21])=[O:20].[CH2:34](N(CC)CC)[CH3:35].CCN=C=NCCCN(C)C>CN(C1C=CN=CC=1)C.C(Cl)Cl.C(Cl)(Cl)Cl>[CH2:34]([O:21][C:19](=[O:20])[CH2:22][CH2:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](=[O:30])[NH:18][CH2:17][C:3]2[N:4]=[C:5]([C:7]3[CH:8]=[CH:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=3)[O:6][C:2]=2[CH3:1])=[CH:26][C:25]=1[CH3:33])[CH3:35]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

8

반응물 4

HCID 8471TriethylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 58765787C-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-methylamineHCID 694730814-(2-Carboxy-ethyl)-3-methyl-benzoic acid

생성물 1

HCID 694707913-(2-Methyl-4-{[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-carbamoyl}-phenyl)-propionic acid ethyl ester

시약·촉매·용매

3
HCID 142844-(Dimethylamino)pyridine촉매HCID 6212Chloroform용매HCID 6344Dichloromethane용매

실험 절차

To a mixture of C-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-methylamine (0.2 g, 0.78 mmol) and 4-(2-carboxy-ethyl)-3-methyl-benzoic acid (0.173 g, 0.78 mmol) and DMAP (5 mg) in methylene chloride (5 mL) are added triethyl amin (0.12 mL, 0.86 mml) and EDCI (150 mg, 0.78 mmol) at room temperature. After stirred for 3 hrs, diluted with chloroform, washed with water, 1N HCl and 2 N NaOH aqueous. Concentration and column chromatography on silica gel gave the title compound (240 mg).

후처리

  1. washwashed with water, 1N HCl and 2 N NaOH aqueous
  2. concentrationConcentration and column chromatography on silica gel

출처 및 근거

ORD 기록
ord-e7239e7ef55f4c18bc06ec2520623b1b
출처 데이터셋
uspto-grants-2007_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07259175B2

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