Hydrochloric Acid → (4-Tert-butyl-benzyl)-[2-(4-difluoromethoxy-phenyl)-ethyl]-amine

HRID 855200

반응식

HRID 855200 반응식
[C:1]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.[F:14][CH:15]([F:26])[O:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][NH2:25])=[CH:19][CH:18]=1.C(=O)([O-])[O-].[K+].[K+].[BH4-].[Na+].Cl>CO>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH:25][CH2:24][CH2:23][C:20]2[CH:19]=[CH:18][C:17]([O:16][CH:15]([F:14])[F:26])=[CH:22][CH:21]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 703244-tert-ButylbenzaldehydeHCID 4311764Sodium borohydrideHCID 534444412-(4-(Difluoromethoxy)phenyl)ethan-1-amine hydrochloride

생성물 1

HCID 69341978(4-Tert-butyl-benzyl)-[2-(4-difluoromethoxy-phenyl)-ethyl]-amine수율 80%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1.12 ml of 4-tert-butylbenzaldehyde (6.71 mmol), 1 g of 2-(4-difluoromethoxy-phenyl)-ethylamine hydrochloride (4.47 mmol) and 618 mg of potassium carbonate (4.47 mmol) were suspended in 13 ml methanol at rt, and after stirring for 30 min at rt, were refluxed for 2 h. After cooling down to rt, 254 mg (6.71 mmol) sodium borohydride were added and after stirring for 5 min at rt, the reaction mixture was then refluxed for 2.5 h. After cooling down to rt, the reaction mixture was treated with 1.2 ml 1 N HCl and concentrated in vacuo. The residue was diluted with water/EtOAc. After separation of the organic phase, the aqueous phase was extracted with EtOAc and the combined organic phases were washed with brine, dried with magnesium sulfate, filtered off and concentrated in vacuo. The residue was purified by column chromatography (40 g silica gel; EtOAc/heptane 1:4) to give 1.19 g light yellow oil (80%). MS (ISP) 334.3 (M+H)+.

후처리

  1. temperaturewere refluxed for 2 h
  2. temperatureAfter cooling down to rt
  3. stirringafter stirring for 5 min at rt
  4. temperaturethe reaction mixture was then refluxed for 2.5 h
  5. temperatureAfter cooling down to rt
  6. concentrationconcentrated in vacuo
  7. additionThe residue was diluted with water/EtOAc
  8. customAfter separation of the organic phase
  9. extractionthe aqueous phase was extracted with EtOAc
  10. washthe combined organic phases were washed with brine
  11. dry with materialdried with magnesium sulfate
  12. filtrationfiltered off
  13. concentrationconcentrated in vacuo
  14. customThe residue was purified by column chromatography (40 g silica gel; EtOAc/heptane 1:4)

출처 및 근거

ORD 기록
ord-83457a1aaa0b45129d2de660cfba4e43
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07259183B2

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