Hydrazine hydrate (1:1) → 3-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-5-one

HRID 855705

반응식

HRID 855705 반응식
C([O:3][C:4](=O)[CH2:5][C:6]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)=O)C.O.[NH2:16][NH2:17]>>[N:10]1[CH:11]=[CH:12][CH:13]=[C:8]([C:6]2[CH2:5][C:4](=[O:3])[NH:17][N:16]=2)[CH:9]=1

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 222197Ethyl 3-oxo-3-(pyridin-3-yl)propanoate

생성물 1

HCID 124483833-(pyridin-3-yl)-4,5-dihydro-1H-pyrazol-5-one수율 50%

실험 절차

The starting material was prepared using an analogous procedure to that described in Example 9. Ethyl-2-(3-pyridylcarbonyl)acetate (1 g, 5.18 mmol) was treated with hydrazine hydrate (251 μl, 5.2 mmol) to give 3-(3-pyridyl)-4,5-dihydro-1H-pyrazol-5-one (413 mg, 50%).

후처리

  1. customThe starting material was prepared

출처 및 근거

ORD 기록
ord-e6da0555092e4373938afa6d5a060041
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262201B1

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