4-Aminothiophenol → HCID 22938738, 화합물

HRID 856660노트

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HRID 856660 반응식
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[CH2:11]O.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([SH:20])=[CH:16][CH:15]=1.[OH-].[Na+]>Cl>[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20][CH2:11][C:10]2[N:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]3=[N:3][C:2]=2[CH3:1])=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 145104-AminothiophenolHCID 14798Sodium HydroxideHCID 7060539(2-methylimidazo[1,2-a]pyridin-3-yl)methanol

생성물 1

HCID 22938738HCID 22938738, 화합물수율 22.2%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Under nitrogen atmosphere, to a suspension of aluminum lithium hydride (1.6 g) in THF (100 ml) was added dropwise a solution of ethyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate (8.56 g) in THF (100 ml) at 0° C. under nitrogen atmosphere. The mixture was stirred for 1 hour at 0° C., water (1.6 ml), 15% aqueous solution of sodium hydroxide (1.6 ml) and water (4.8 ml) were sequentially and slowly added dropwise to the solution, and the mixture was stirred for 2 hours at room temperature. To the reaction solution was added magnesium sulfate, and the precipitates were removed by filtration. The mixture was concentrated under reduced pressure, to give 2-methylimidazo[1,2-a]pyridine-3-methanol (6.45 g) as pale yellow amorphous. A mixture of 2-methylimidazo[1,2-a]pyridine-3-methanol (1 g) and 4-aminothiophenol (0.65 g) in concentrated hydrochloric acid (10 ml) was stirred for 18 hours at room temperature. 8N aqueous solution of sodium hydroxide was added to adjust pH to 10 at 0° C. and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The obtained residue was separated and purified by column chromatography (ethanol:ethyl acetate 1:4), to give 3-(4-aminophenylthiomethyl)-2-methylimidazo[1,2-a]pyridine (311 mg) as colorless crystals.

후처리

  1. customat 0° C.
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe obtained residue was separated
  7. custompurified by column chromatography (ethanol:ethyl acetate 1:4)

출처 및 근거

ORD 기록
ord-c56f7a404e4744048910b2a24ee57ce3
출처 데이터셋
uspto-grants-2007_08
특허 번호
US07262185B2

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