홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → 2-(4-Chloro-phenyl)-cyclopropanecarboxylic acid[1-(2,3-dihydro-benzofuran-5-yl)-ethyl]-amide

HRID 857027
노트
인쇄 미리보기

반응식

HRID 857027 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([NH2:12])[CH3:11])=[CH:9][C:4]=2[CH2:3][CH2:2]1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([CH:20]2[CH2:22][CH:21]2[C:23](O)=[O:24])=[CH:16][CH:15]=1.CCN=C=NCCCN(C)C.Cl.C(N(CC)CC)C>CN(C1C=CN=CC=1)C.ClCCl>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([NH:12][C:23]([CH:21]3[CH2:22][CH:20]3[C:17]3[CH:16]=[CH:15][C:14]([Cl:13])=[CH:19][CH:18]=3)=[O:24])[CH3:11])=[CH:9][C:4]=2[CH2:3][CH2:2]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 2374122-(4-Chlorophenyl)cyclopropanecarboxylic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 167684331-(2,3-Dihydro-1-benzofuran-5-yl)ethan-1-amine

생성물 1

HCID 218646792-(4-Chloro-phenyl)-cyclopropanecarboxylic acid[1-(2,3-dihydro-benzofuran-5-yl)-ethyl]-amide수율 67.3%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of 1-(2,3-dihydro-benzofuran-5-yl)-ethylamine (0.1 mmol), 2-(4-Chloro-phenyl)-cyclopropanecarboxylic acid (0.1 mmol), EDAC.HCl (0.2 mmol), DMAP (0.2 mmol), and triethylamine (0.4 mmol) in dichloromethane (2 mL) was stirred at room temperature overnight. The reaction mixture was purified by flash chromatography eluting with 50% hexanes in ethyl acetate to give the title compound (23 mg) as a solid.

후처리

  1. customThe reaction mixture was purified by flash chromatography
  2. washeluting with 50% hexanes in ethyl acetate

출처 및 근거

ORD 기록
ord-b6d9a95b08cf494c8c565a162455954c
출처 데이터셋
uspto-grants-2006_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07144881B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트