Ethyl chloroacetate → 1-(3-Iodophenyl)-2,4-imidazolidinedione

HRID 857103노트

반응식

HRID 857103 반응식
[I:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([NH2:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].Cl[CH2:15][C:16](OCC)=[O:17]>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:15][C:16](=[O:17])[NH:11][C:9]2=[O:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 7751Ethyl chloroacetateHCID 24758Sodium hydrideHCID 21867173(3-iodophenyl)urea

생성물 1

HCID 218671771-(3-Iodophenyl)-2,4-imidazolidinedione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 3-iodophenylurea (2.1 g) in DMF (20 ml) was treated with sodium hydride (60% oil dispersion; 640 mg), followed by ethyl chloroacetate (0.93 ml) and the mixture was stirred for 5 h. The mixture was partitioned between EtOAc and 2M HCl and the organic solution was washed with NaHCO3, brine, dried and evaporated to dryness to give the title compound (2.08 g) ES+ve 303(MH)+.

후처리

  1. customThe mixture was partitioned between EtOAc and 2M HCl
  2. washthe organic solution was washed with NaHCO3, brine
  3. customdried
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-b5db57e3fd204cacb9fdda816d0786a8
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144908B2

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