Hydrochloric Acid → 3-(3-Iodophenyl)imidazolidine-2,4-dione
반응식
[I:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([NH:11][CH2:12][C:13]([O:15]CC)=O)=[O:10])[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].Cl>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([N:8]2[C:13](=[O:15])[CH2:12][NH:11][C:9]2=[O:10])[CH:5]=[CH:6][CH:7]=1참가 물질
5
실험 절차
A solution of ethyl N-{[(3-iodophenyl)amino]carbonyl}glycinate (9.42 g) in DMF (60 ml) was treated with sodium hydride (60% oil dispersion, 1.2 g) at 20° C. After 2 h the reaction mixture was treated with aqueous 2M HCl (200 ml) and stirred overnight. The solid was collected by filtration, washed with water and dried to give the title compound (6.9 g) LCMS RT=2.45 min.
후처리
- filtrationThe solid was collected by filtration
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-64023520ea564a86a19be31abc8c1cae
- 출처 데이터셋
- uspto-grants-2006_12
- 특허 번호
- US07144908B2
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