Hydrochloric Acid → HCID 21867183, 화합물

HRID 857126노트

반응식

HRID 857126 반응식
[I:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][C:11](=[O:13])[NH:10][C:9]2=[O:14])[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.Cl>CN(C=O)C>[CH2:17]([N:10]1[C:11](=[O:13])[CH2:12][N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([I:1])[CH:3]=2)[C:9]1=[O:14])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 218671771-(3-Iodophenyl)-2,4-imidazolidinedione

생성물 1

HCID 21867183HCID 21867183, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1-(3-Iodophenyl)imidazolidine-2,4-dione (0.5 g) was taken up in dry DMF (10 ml) and treated with sodium hydride (60% oil dispersion, 73 mg) and stirred for 20 min under nitrogen. Benzyl bromide (0.295 ml) was added and stirring continued for 3 h. 2M HCl (100 ml) was added and the mixture extracted with EtOAc. The combined extracts were washed with saturated aqueous sodium hydrogen carbonate (50 ml), brine (50 ml) and dried (MgSO4). This was recrystallised from MeOH to give the title compound (0.255 g). LCMS RT 3.53 min.

후처리

  1. stirringstirring
  2. waitcontinued for 3 h
  3. extractionthe mixture extracted with EtOAc
  4. washThe combined extracts were washed with saturated aqueous sodium hydrogen carbonate (50 ml), brine (50 ml)
  5. dry with materialdried (MgSO4)
  6. customThis was recrystallised from MeOH

출처 및 근거

ORD 기록
ord-dcd6f19d0f474d478dc5b878332a5e60
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144908B2

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