Hydrochloric Acid → HCID 21867424, 화합물

HRID 857395

반응식

HRID 857395 반응식
[Br:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([C:12](OC)=[O:13])[NH:6]2.[H-].C([Al+]CC(C)C)C(C)C.Cl>C1COCC1>[Br:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH2:12][OH:13])[NH:6]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 21225700DiisobutylaluminumhydrideHCID 21867463Methyl 4-bromo-6-fluoro-1H-indole-2-carboxylate

생성물 1

HCID 21867424HCID 21867424, 화합물수율 96.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
-30 °C

실험 절차

To a solution of methyl 4-bromo-6-fluoro-1H-indole-2-carboxylate (3 g, 11 mmol) in THF (50 mL) at −30° C. was added diisobutylaluminum hydride (33 mmol, 1.5M toluene solution). The mixture was stirred for 1 hour at −30° C. and 1N HCl was added. The phases were separated and the aqueous layer was extracted with Et2O. The combined organic layers were dried over Na2SO4 and concentrated to give 2.6 g of the title compound used as such.

후처리

  1. customThe phases were separated
  2. extractionthe aqueous layer was extracted with Et2O
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-62c19ebd538d4c77bd4a41527a3c3744
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07144913B2

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