Hydrochloric Acid → HCID 178473974, 화합물

HRID 858298

반응식

HRID 858298 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2].[N:14]1[CH:19]=[CH:18][N:17]=[CH:16][C:15]=1[C:20](O)=[O:21].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(C(C)C)C(C)C)C.Cl>CN(C=O)C>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:20]([OH:21])[C:15]2[CH:16]=[N:17][CH:18]=[CH:19][N:14]=2)[C:5]1=[O:13])(=[O:3])[CH3:2]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 10472-Pyrazinecarboxylic acidHCID 81531DiisopropylethylamineHCID 3237191-Acetylindolin-2-oneHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

생성물 1

HCID 178473974HCID 178473974, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4.38 g 1-acetyl-2-indolinone, 3.41 g pyrazine-2-carboxylic acid, 8.83 g TBTU, 4.21 g HOBT-hydrate and 21.8 ml ethyldiisopropylamine are stirred in 70 ml DMF for 15 hours at ambient temperature. The mixture is poured onto 400 ml ice water and 10 ml of conc. hydrochloric acid and stirred for 1 hour. The precipitate is suction filtered, washed with water, stirred with methanol, suction filtered again, washed with methanol and dried at 100° C.

후처리

  1. filtrationfiltered
  2. washwashed with water
  3. stirringstirred with methanol, suction
  4. filtrationfiltered again
  5. washwashed with methanol
  6. customdried at 100° C.

출처 및 근거

ORD 기록
ord-7a56fe76223341628f39ab52bed4f6ba
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07148249B2

연결된 노트

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