Hydrochloric Acid → 5-Chloronicotinic acid

HRID 860495노트

반응식

HRID 860495 반응식
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([O-:9])=[O:8].[OH-].[Na+].Cl>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69943215-Chloronicotinate

생성물 1

HCID 2479865-Chloronicotinic acid수율 65.3%

반응 조건

온도
60 °C

실험 절차

To 5-chloronicotinate (10.5 g) was added 1N NaOH (84.9 mL) at ambient temperature. The mixture was heated at 60° C. for 1 hour. The reaction mixture was adjusted to pH 4–5 with HCl. The precipitate was filtered to give 5-chloronicotinic acid (6.9 g) a colorless solid.

후처리

  1. filtrationThe precipitate was filtered

출처 및 근거

ORD 기록
ord-537602e154b04d0cbb337da3de6eb777
출처 데이터셋
uspto-grants-2006_12
특허 번호
US07153854B2

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