Water → Benzoic acid, 4-iodo-2-methoxy-, methyl ester

HRID 861785

반응식

HRID 861785 반응식
[H-].[Na+].[OH:3][C:4]1[CH:13]=[C:12]([I:14])[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7].I[CH3:16].O>CN(C=O)C>[I:14][C:12]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:3][CH3:16])[CH:13]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 11380407Methyl 4-iodosalicylate

생성물 1

HCID 22619468Benzoic acid, 4-iodo-2-methoxy-, methyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

238 mg (7.9 mmol) of sodium hydride (80% in oil) and 20 ml of DMF were introduced into a three-necked flask, a solution of 2 g (7.2 mmol) of methyl 2-hydroxy-4-iodobenzoate in 50 ml of DMF was added dropwise and stirring was carried out until gas evolution had ceased. 540 μl (8.6 mmol) of iodomethane were then added and stirring was carried out at room temperature for two hours. The reaction mixture was poured into water and extracted with ethyl ether. The organic phase was separated by settling, dried over magnesium sulfate and evaporated. 2.1 g (100%) of methyl 4-iodo-2-methoxybenzoate were recovered.

후처리

  1. stirringstirring
  2. extractionextracted with ethyl ether
  3. customThe organic phase was separated
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. custom2.1 g (100%) of methyl 4-iodo-2-methoxybenzoate were recovered

출처 및 근거

ORD 기록
ord-753be02e07084d23862382f5394502aa
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05716624

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