Trifluoroacetic acid → 3-(Piperidin-4-ylmethyl)pyridine

HRID 862737노트

반응식

HRID 862737 반응식
CC(C)(OC([N:7]1[CH2:12][CH2:11][CH:10]([CH2:13][C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[CH2:9][CH2:8]1)=O)C.FC(F)(F)C(O)=O.[OH-].[Na+]>C(Cl)(Cl)Cl>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([CH2:13][CH:10]2[CH2:11][CH2:12][NH:7][CH2:8][CH2:9]2)[CH:15]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 185388801-(1,1-Dimethylethyloxycarbonyl)-4-(3-pyridylmethyl)piperidine

생성물 1

HCID 37932203-(Piperidin-4-ylmethyl)pyridine수율 95%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of 1-(1,1-dimethylethyloxycarbonyl)-4-(3-pyridylmethyl)piperidine (500 mg, 1.80 mmol) in chloroform (14 mL) was cooled to 0° C. and treated with trifluoroacetic acid (5 mL, 65.14 mmol). The resulting mixture was stirred for 1 h and then made basic by addition of aqueous sodium hydroxide. The organic extracts were separated and the aqueous was reextracted three more times with chloroform. The chloroform extracts were combined, dried over sodium sulfate, filtered and concentrated on a rotary evaporator to give the title compound as a colorless oil (300 mg, 1.70 mmol, 95%).

후처리

  1. customThe organic extracts were separated
  2. dry with materialdried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated on a rotary evaporator

출처 및 근거

ORD 기록
ord-fb6be0b8edce460b8568a5637de71777
출처 데이터셋
uspto-grants-1998_02
특허 번호
US05719166

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